Preimplantation genetic diagnosis, embryo slection

Kuliev, Anver, and Yury Verlinsky. "Preimplantation diagnosis: a realistic option for assisted reproduction and genetic practice." Current Opinion in Obstetrics and Gynecology 17.2 (2005): 179-183.

Preimplantation diagnosis a realistic option for assisted reproduction and genetic practice

Purpose of review

Preimplantation genetic diagnosis (PGD) allows genetically

disadvantaged couples to reproduce, while avoiding the

birth of children with targeted genetic disorders. By

ensuring unaffected pregnancies, PGD circumvents the

possible need and therefore risks of pregnancy termination.

This review will describe the current progress of PGD for

Mendelian and chromosomal disorders and its impact on

reproductive medicine.

Recent findings

Indications for PGD have expanded beyond those used in

prenatal diagnosis, which has also resulted in improved

access to HLA-compatible stem-cell transplantation for

siblings through preimplantation HLA typing. More than

1000 apparently healthy, unaffected children have been

born after PGD, suggesting its accuracy, reliability and

safety. PGD is currently the only hope for carriers of

balanced translocations. It also appears to be of special

value for avoiding age-related aneuploidies in in-vitro

fertilization patients who have a particularly poor prognosis

for a successful pregnancy; the accumulated experience of

thousands of PGD cycles strongly suggests that PGD can

improve clinical outcome for such patients.

Summary

PGD would particularly benefit poor prognosis in-vitro

fertilization patients and other at-risk couples by improving

reproductive outcomes and avoiding the birth of affected

offspring.

Verlinsky, Yury, et al. "Over a decade of experience with preimplantation genetic diagnosis: a multicenter report." Fertility and sterility 82.2 (2004): 292-294.

Over a decade of experience with preimplantation genetic diagnosis a multicenter report

Harper, Joyce C., and Sioban B. SenGupta. "Preimplantation genetic diagnosis: state of the art 2011." Human genetics 131.2 (2012): 175-186.

Preimplantation genetic diagnosis State of the ART 2011

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