You can't ignore gene-environment correlations when looking for gene-environment interactions
www.emilkirkegaard.com
Humans love interactions, they tell interesting stories (however, no study has investigated this bias, AFAIK). However, statistics and nature hate interactions. Interactions in general have low prior, and because people fail to realize this properly, reports of interactions generally fail to replicate. This is also true for gene-environment interactions (GxE), the love-child of any would be behavioral genetics critic (strong interactions make standard ANOVA of family data very tricky and thus lets critics retreat into 'it's too complicated, we don't know anything' territory).
You can't ignore gene-environment correlations when looking for gene-environment interactions
You can't ignore gene-environment…
You can't ignore gene-environment correlations when looking for gene-environment interactions
Humans love interactions, they tell interesting stories (however, no study has investigated this bias, AFAIK). However, statistics and nature hate interactions. Interactions in general have low prior, and because people fail to realize this properly, reports of interactions generally fail to replicate. This is also true for gene-environment interactions (GxE), the love-child of any would be behavioral genetics critic (strong interactions make standard ANOVA of family data very tricky and thus lets critics retreat into 'it's too complicated, we don't know anything' territory).